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Caspase-1-dependent pyroptosis converts αSMA+ CAFs into collagen-IIIhigh iCAFs to fuel chemoresistant cancer stem cells
Date: June 13, 2025 PMID: PMC12154229 Category: N/A Authors: Hongbo Gao, Stephen Q R Wong, Ethan Subel, Yung Hsing Huang, Yu-Cheng Lee, Kazukuni Hayashi, Mark Ellie Alonzo, Mustafa Karabicici, Xen Ping Hoi, Armine Kasabyan 1, Qianxing Mo, Zachary Melchiode, Ziad El-Zaatari, Steven Shen, Raj Satkunasivam, Fotis Nikolos, Keith Syson Chan Abstract: 40498841 The impact of chemotherapy-induced tumor cell pyroptosis on fibroblasts, a key stromal cell type within the tumor microenvi
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Nov 4, 20252 min read
Oncogenic and tumor-suppressive forces converge on a progenitor-orchestrated niche to shape early tumorigenesis
Date: June 12, 2025 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC12259082/ Category: N/A Authors: José Reyes, Isabella Del Priore, Andrea C Chaikovsky, Nikhita Pasnuri, Ahmed M Elhossiny, Tobias Krause, Andrew Moorman, Catherine Snopkowski, Meril Takizawa, Cassandra Burdziak, Nalin Ratnayeke, Ignas Masillioni, Yu-Jui Ho, Ronan Chaligné, Paul B Romesser, Aveline Filliol, Tal Nawy, John P Morris, Zhen Zhao, Marina Pasca Di Magliano, Direna Alonso-Curbelo, Dana Pe'er, Scott W
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Nov 4, 20252 min read
Thor: a platform for cell-level investigation of spatial transcriptomics and histology
Date: August 5, 2025 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC12325965/ Category: N/A Authors: Pengzhi Zhang, Weiqing Chen, Tu N Tran, Minghao Zhou, Kaylee N Carter, Ibrahem Kandel, Shengyu Li, Xen Ping Hoi, Yuxing Sun, Li Lai, Keith Youker, Qianqian Song, Yu Yang, Fotis Nikolos, Zejuan Li, Keith Syson Chan, John P Cooke, Guangyu Wang Abstract: 40764306 Spatial transcriptomics links gene expression with tissue morphology, however, current tools often prioritize genomic
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Nov 4, 20252 min read
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