Date: June 2026 PMCID: https://pmc.ncbi.nlm.nih.gov/articles/PMC13310799/ Category: N/A Authors: Toru Sakatani, Sunao Tanaka, Kaoru Murakami, Cynthia Jinno, Francisco Aguilar, Catherine Bresee, Owen T M Chan, Daniel J Luthringer, Alberto Contreras-Sanz, Peter Black, Charles J Rosser, Hideki Furuya Abstract: The CXCR2-CXCL1 axis is critical in tumorigenesis, specifically, CXCL1 is a secreted chemokine implicated in tumor progression, angiogenesis, and immune modulation. A

Date: August 10, 2026 PMID: 42573944 Category: N/A Authors: Kai Chen, Yixuan Zhao, Kentaro Takeda, Ying Yuan Abstract: The US Food and Drug Administration (FDA) launched Project Optimus and issued guidance to reform dose-finding and selection trials, shifting the paradigm from identifying the maximum tolerated dose (MTD) to determining the optimal biological dose (OBD), which optimizes the risk and benefit of treatments. The FDA's guidance emphasizes the importance of co

Date: May 18, 2026 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC13352979/ Category: N/A Authors: Zhiyong He, Yves Konigshofer, Russell Garlick, Jayanthi Ramprakash, Madhumita Ramesh, Eric Hall, Adam Corner, Michelle Clarissa, Jocelyn H Wright, Victoria K Cannon, Ming Yu, William M Grady, Cecilia C S Yeung, Zachary Heimer, Zhili Wang, ShiPing Zou, Shidong Jia, Fang Liu, Giancarlo Bonora, Karol Bomsztyk, Daniel Mar, Kenneth D Cole, Hua-Jun He Abstract: Background: Aberra

Date: February 28, 2026 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC12998610/ Category: N/A Authors: Jacob T Mitchell, Orian Stapleton, Kavita Krishnan, Sushma Nagaraj, Dmitrijs Lvovs, Christopher Cherry, Amanda Poissonnier, Wesley Horton, Andrew Adey, Varun Rao, Amanda Huff, Jacquelyn W Zimmerman, Luciane T Kagohara, Neeha Zaidi, Lisa M Coussens, Elizabeth M Jaffee, Jennifer H Elisseeff , Elana J Fertig Abstract: Motivation: Algorithms for ligand-receptor network inf

Date: July 1, 2026 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC13320202/ Category: N/A Authors: Emily Alger, Ruitao Lin, J Jack Lee, Ying Yuan, Christina Yap Abstract: Purpose: The primary objective of dose-finding oncology trials (DFOT) is to determine the recommended phase II dose. Although dose selection has traditionally relied on clinician-reported safety outcomes, the goal of DFOTs increasingly focuses on the integration of safety, activity, and tolerability wit

Date: March 17, 2026 PMCID: https://pmc.ncbi.nlm.nih.gov/articles/PMC12995303/ Category: N/A Authors: Chenxuan Zang, Charles C Guo, Yaohong Wang, Peng Wei, Ziyi Li Abstract: The identification of tumor cells is pivotal for understanding tumor heterogeneity and the tumor microenvironment. Recent advances in spatially resolved transcriptomics (SRT) have revolutionized the way that transcriptomic profiles are characterized and have enabled the simultaneous quantification of

Date: April 8, 2026 PMCID: https://pmc.ncbi.nlm.nih.gov/articles/PMC13174004/ Category: N/A Authors: Li-Ting Ku, Vincent Bernard, Jimin Min, Ying Yuan, Eugene Jon Koay, Anirban Maitra, Liang Li, Ziyi Li Abstract: Background: Cell-cell communication via ligand-receptor signaling is a fundamental mechanism shaping multicellular organization and functional heterogeneity within tissue microenvironments. Recent advances in spatial transcriptomics (ST) have enabled unprecedent

Date: April 1, 2026 PMCID: https://pmc.ncbi.nlm.nih.gov/articles/PMC13060245/ Category: N/A Authors: Dmitrijs Lvovs, Jeffrey Quinn, André Forjaz, Ivette Santana-Cruz, Orian Stapleton, Kranthi Vavikolanu, Meredith Wetzel; Demystifying Pancreatic Cancer Therapies TeamLab; Data Science Hub Teamlab; Vincent Bernard, Brian R Herb, Alexander Favorov, Luciane T Kagohara, Ashley L Kiemen, Anirban Maitra, Dimitrios N Sidiropoulos, Wesley Tansey, Laura D Wood, Atul Deshpande, Michael N

Date: August 4, 2026 PMID: 42547816 Category: N/A Authors: Seong-Woo Bae, Aristotelis Tsirigos, Jimin Min, Anirban Maitra Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a complex disease characterized by high levels of cellular heterogeneity and pronounced microenvironmental remodelling. Dynamic changes during its initiation and progression contribute to resistance to conventional therapies. Building upon key molecular catalogues established by bulk and single-cell

Date: September 2026 PMCID: https://pmc.ncbi.nlm.nih.gov/articles/PMC13424723/ Category: N/A Authors: Ruiying Hu, Nala Hamilton, Yu Wang, Xin Tong, Mahircan Yagan, Prasanna K Dadi, Cristina Harmelink, Teri D Doss, Jinhua Liu, Yanwen Xu, Alan J Simmons, Ken S Lau, Roland Stein, Appakalai N Balamurugan, Irina Kaverina, Katie C Coate, David A Jacobson, Qi Liu, Guoqiang Gu Abstract: Aims/hypothesis: Genetic and environmental factors work together to cause islet beta cell fai

Date: February 20, 2026 PMCID: https://pmc.ncbi.nlm.nih.gov/articles/PMC12922755/ Category: N/A Authors: Christopher Douville, Jeeun Parksong, Marco Dal Molin, Sarah Graham, Patricia T Greipp, Ryan Knudson, Samuel Curtis, Yuxuan Wang, Lisa Dobbyn, Maria Popoli, Janine Ptak, Natalie Silliman, Katharine Romans, Christine A Iacobuzio-Donahue, Alvin P Makoohon-Moore, Anne Marie Lennon, Michael Goggins, Ralph H Hruban, Ashley Kiemen, Chetan Bettegowda, Kenneth W Kinzler, Nickolas

Date: August 4, 2026 PMCID: https://pmc.ncbi.nlm.nih.gov/articles/PMC13429029/ Category: N/A Authors: Yaqing Zhang, Padma Kadiyala, Wei Yan, Kristee Brown, Faith R Avritt, Katelyn L Donahue, Megan C Procario, Jude O Okoye, Thejaswini Giridharan, Ahmed M Elhossiny, Carlos E Espinoza, Dominik Awad, Emily L Lasse Opsahl, Paola I Medina-Cabrera, Ashley Velez-Delgado, Rosa E Menjivar, Olivia A Yang, Sion Yang, Xi He, Shruti Gupta, Rahma Tariq, Anona R Brandt, Xinyu Wang, Aaron den

Date: April 20, 2026 PMCID: https://pmc.ncbi.nlm.nih.gov/articles/PMC13216336/ Category: N/A Authors: Stephen Qr Wong, Kazukuni Hayashi, Ethan J Subel, Yung Hsing Huang, Hongbo Gao, Haley E Garcia, Sophie J Porter, Mustafa Karabicici, Xen Ping Hoi, Mark D Alonzo, Armine Kasabyan, Efrosini Tsouko, Crystal S Shin, Lisa Bouchier-Hayes, Dimitrios Korentzelos, Chen Chen, Michael Brooks, Zheng Yin, Renil S Titus, Lan Zhou, Yinan Gong, Yulin Li, Stephen Tc Wong, Ziad El-Zaatari, Dha

Date: March 16, 2026 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC13139388/ Category: N/A Authors: Anika Gupta, Norma Morella, Dmitry Sutormin, Naisi Li, Karl Gaisser, Alexander Robertson, Yaroslav Ispolatov, Georg Seelig, Neelendu Dey, Anna Kuchina Abstract: The interactions between lytic phages and their hosts are typically studied in bulk culture, which obscures cell-cell differences in infection susceptibility or expression of protective factors. Here, we use bacte

Date: July 1, 2026 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC13289816/ Category: N/A Authors: Jimin Min, Lisa Schweizer, Gijs Zonderland, Benson Chellakkan Selvanesan, Julie H Thomsen, Lukas Oldenburg, Seong-Woo Bae, Bongjun Kim, Sharía D Hernández, Gabriela Jez, Vincent Bernard, Benjamin J Swanson, Kelsey A Klute, Huamin Wang, Thomas C Caffrey, Paul M Grandgenett, Michael A Hollingsworth, Ishani Ummat, Maximilian T Strauss, Andreas Mund, Anirban Maitra Abstract: Pa

Date: April 8, 2026 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC13121030/ Category: N/A Authors: Megan D Radyk, Barbara S Nelson, Mariana Tannus Ruckert, Christopher J Halbrook, Mengrou Shan, Jonathan M Alektiar, Brooke L Lavoie, Lucie Salvatore, Wei Yan, Matthew D Perricone, Kathryn Buscher, Alexander Wood, Hanna S Hong, Peter Sajjakulnukit, Li Zhang, Gabriel Corfas, Filip Bednar, Timothy L Frankel, Marina Pasca di Magliano, Justin A Colacino, Yatrik M Shah, Howard C Craw

Date: July 11, 2026 PMID: 42436354 Category: N/A Authors: Kathleen M McAndrews, Krishnan K Mahadevan, Bingrui Li, Anaïs M Comptdaer, Amari M Sockwell, Sami J Morse, Patience J Kelly, Sarah I Patel, Michelle L Kirtley, Barbara A Moreno Diaz, Hengyu Lyu, David H Peng, Sima Khazaei, Aislyn Schalck, Xunian Zhou, Hikaru Sugimoto, Aaron A Bickert, Lakshmi Kavitha Sthanam, Meagan R Taylor, Shreyasee V Kumbhar, Kent A Arian, Yasaman Barekatain, Francesca Paradiso, Paola A Guerrero, V

Date: March 5, 2026 PMCID: https://pmc.ncbi.nlm.nih.gov/articles/PMC13147340/ Category: N/A Authors: Brandon Chen, Drew C Stark, Pankaj V Jadhav, Theophilus M Lynn-Nguyen, Benjamin S Halligan, Nicholas J Rossiter, Nicole Sindoni, Myungsun Shin, Joao A Paulo, Matthew Chang, Imhoi Koo, Sergei Koshkin, Sanjana Eyunni, Paolo Ronchi, Michelle T Paulsen, Harrison S Greenbaum, Mariana T Ruckert, Pietro Morlacchi, David A Hanna, Jason Lin, Rachel M Guerra, Tao Liu, David J Pagliarini

Date: January 2025 PMID: Category: N/A Authors: Tanaka, S (Tanaka, Sunao), Murakami, K (Murakami, Kaoru), Sakatani, T (Sakatani, Toru), Lee, RK (Lee, Riko), Hogrefe, W (Hogrefe, Wayne), Siguencia, F (Siguencia, Fernando), Rosser, CJ (Rosser, Charles J.), Furuya, H (Furuya, Hideki) DOI: 10.3390/diagnostics15020138 Background/Objectives: Urinalysis accuracy requires reliable sample stability that is dependent on the chosen collection and storage conditions. The multiplex Onc

Date: July 9, 2025 PMID: Category: N/A Authors: Wang, J (Wang, Jing), Chen, HC (Chen, Hua-chang), Hiebert, SW (Hiebert, Scott W.), Sheng, QH (Sheng, Quanhu), Tansey, WP (Tansey, William P.), Shyr, Y (Shyr, Yu), Liu, Q (Liu, Qi) DOI: 10.1093/gigascience/giaf071 Nascent RNA sequencing tracks primary transcriptional events, making it crucial for studying the immediate regulatory changes of genes and enhancers in response to both endogenous and exogenous stimuli. NRSA is a w