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Targeting PIKfyve-driven lipid metabolism in pancreatic cancer
Date: June 2025 PMID: PMC12176661 Category: N/A Authors: Caleb Cheng, Jing Hu, Rahul Mannan, Tongchen He, Rupam Bhattacharyya, Brian Magnuson, Jasmine P Wisniewski, Sydney Peters, Saadia A Karim, David J MacLean, Hüseyin Karabürk, Li Zhang, Nicholas J Rossiter, Yang Zheng, Lanbo Xiao, Chungen Li, Dominik Awad, Somnath Mahapatra, Yi Bao, Yuping Zhang, Xuhong Cao, Zhen Wang, Rohit Mehra, Pietro Morlacchi, Vaibhav Sahai, Marina Pasca di Magliano, Yatrik M Shah, Lois S Weisman, J
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2 days ago2 min read
Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer
Date: June 2025 PMID: 40269162 Category: N/A Authors: Guangsheng Pei, Jimin Min, Kimal I Rajapakshe, Vittorio Branchi, Yunhe Liu, Benson Chellakkan Selvanesan, Fredrik Thege, Dorsay Sadeghian, Daiwei Zhang, Kyung Serk Cho, Yanshuo Chu, Enyu Dai, Guangchun Han, Mingyao Li, Cassian Yee, Kazuki Takahashi, Bharti Garg, Herve Tiriac, Vincent Bernard, Alexander Semaan, Jean L Grem, Thomas C Caffrey, Jared K Burks, Andrew M Lowy, Andrew J Aguirre, Paul M Grandgenett, Michael A Holli
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2 days ago2 min read
Blebbisomes are large, organelle-rich extracellular vesicles with cell-like properties
Date: March 2025 PMID: PMC11906356 Category: N/A Authors: Dennis K Jeppesen, Zachary C Sanchez, Noah M Kelley, James B Hayes, Jessica Ambroise, Emma N Koory, Evan Krystofiak, Nilay Taneja, Qin Zhang, Matthew M Dungan, Olivia L Perkins, Matthew J Tyska, Ela W Knapik, Kevin M Dean, Amanda C Doran, Robert J Coffey, Dylan T Burnette Abstract: 39984653 Cells secrete a large variety of extracellular vesicles (EVs) to engage in cell-to-cell and cell-to-environment intercellular comm
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2 days ago2 min read
Caspase-1-dependent pyroptosis converts αSMA+ CAFs into collagen-IIIhigh iCAFs to fuel chemoresistant cancer stem cells
Date: June 13, 2025 PMID: PMC12154229 Category: N/A Authors: Hongbo Gao, Stephen Q R Wong, Ethan Subel, Yung Hsing Huang, Yu-Cheng Lee, Kazukuni Hayashi, Mark Ellie Alonzo, Mustafa Karabicici, Xen Ping Hoi, Armine Kasabyan 1, Qianxing Mo, Zachary Melchiode, Ziad El-Zaatari, Steven Shen, Raj Satkunasivam, Fotis Nikolos, Keith Syson Chan Abstract: 40498841 The impact of chemotherapy-induced tumor cell pyroptosis on fibroblasts, a key stromal cell type within the tumor microenvi
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2 days ago2 min read
Oncogenic and tumor-suppressive forces converge on a progenitor-orchestrated niche to shape early tumorigenesis
Date: June 12, 2025 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC12259082/ Category: N/A Authors: José Reyes, Isabella Del Priore, Andrea C Chaikovsky, Nikhita Pasnuri, Ahmed M Elhossiny, Tobias Krause, Andrew Moorman, Catherine Snopkowski, Meril Takizawa, Cassandra Burdziak, Nalin Ratnayeke, Ignas Masillioni, Yu-Jui Ho, Ronan Chaligné, Paul B Romesser, Aveline Filliol, Tal Nawy, John P Morris, Zhen Zhao, Marina Pasca Di Magliano, Direna Alonso-Curbelo, Dana Pe'er, Scott W
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2 days ago2 min read
Thor: a platform for cell-level investigation of spatial transcriptomics and histology
Date: August 5, 2025 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC12325965/ Category: N/A Authors: Pengzhi Zhang, Weiqing Chen, Tu N Tran, Minghao Zhou, Kaylee N Carter, Ibrahem Kandel, Shengyu Li, Xen Ping Hoi, Yuxing Sun, Li Lai, Keith Youker, Qianqian Song, Yu Yang, Fotis Nikolos, Zejuan Li, Keith Syson Chan, John P Cooke, Guangyu Wang Abstract: 40764306 Spatial transcriptomics links gene expression with tissue morphology, however, current tools often prioritize genomic
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2 days ago2 min read
Dipeptidase-1-knockout mice develop invasive tumors with features of microsatellite-unstable colorectal cancer
Date: April 3, 2025 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC12128987/ Category: N/A Authors: Sarah E Glass, Matthew E Bechard, Zheng Cao, Radhika Aramandla, Ping Zhao, Samuel T Ellis, Emily H Green, Elizabeth G Fisher, Ryan T Smith, Chelsie K Sievers, Maria Johnson Irudayam, Frank Revetta, M Kay Washington, Gregory D Ayers, Cody N Heiser, Alan J Simmons, Yanwen Xu, Yu Wang, Annika Windon, Martha J Shrubsole, Nicholas O Markham, Qi Liu, Ken S Lau, Robert J Coffey Abstra
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2 days ago2 min read
Integrated Metabolomics and Spatial Transcriptomics of Cystic Pancreatic Cancer Precursors Reveals Dysregulated Polyamine Metabolism as a Biomarker of Progression
Date: June 13, 2025 PMID: 40184234 Category: N/A Authors: Ricardo A León-Letelier, Yihui Chen, Rongzhang Dou, Ehsan Irajizad, Michele T...
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Jul 292 min read
PIVOT: an open-source tool for multi-omic spatial data registration
Date: June 8, 2025 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC12259011/ Category: N/A Authors: André Forjaz, Valentina Matos Romero,...
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Jul 291 min read
Targeting PIKfyve-driven lipid metabolism in pancreatic cancer
Date: June 2025 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC12176661/ Category: N/A Authors: Caleb Cheng, Jing Hu, Rahul Mannan,...
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Jul 292 min read
Temporally discordant chromatin accessibility and DNA demethylation define short- and long-term enhancer regulation during cell fate specification
Date: May 27, 2025 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC12153380/ Category: N/A Authors: Lindsey N Guerin, Timothy J Scott,...
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Jul 292 min read
Matrix Stiffness and Biochemistry Govern Colorectal Cancer Cell Growth and Signaling in User-Programmable Synthetic Hydrogels
Date: May 12, 2025 PMID: 40304602 Category: N/A Authors: Irina Kopyeva, Ross C Bretherton, Jessica L Ayers, Ming Yu, William M Grady,...
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Jul 292 min read
Dipeptidase-1-knockout mice develop invasive tumors with features of microsatellite-unstable colorectal cancer
Date: April 3, 2025 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC12128987/ Category: N/A Authors: Sarah E Glass, Matthew E Bechard,...
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Jul 292 min read
COMIC: A Bayesian Dose Optimization Design for Drug Combination in Multiple Indications With Application to CAR-T Therapies
Date: May 2025 PMID: 40386962 Category: N/A Authors: Kai Chen, Kentaro Takeda, Ying Yuan Abstract: Project Optimus, initiated by the...
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Jul 292 min read
Multiomic spatial atlas shows deleted in malignant brain tumors 1 (DMBT1) glycoprotein is lost in colonic dysplasia
Date: May 2025 PMID: PMC11985286 Category: N/A Authors: Emily H Green, Subhag R Kotrannavar, Megan E Rutherford, Hannah M Lunnemann,...
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Jul 292 min read
Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms Reveals Divergent Indolent and Malignant States
Date: May 1, 2025 PMID: 39969959 Category: N/A Authors: Matthew K Iyer, Ashley A Fletcher, Jude Ogechukwu Okoye, Chanjuan Shi, Fengming...
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Jul 292 min read
Atf4 Protects Islet β-Cell Identity and Function Under Acute Glucose-Induced Stress but Promotes β-Cell Failure in the Presence of Free Fatty Acid
Date: May 1, 2025 PMID: 39899446 Category: N/A Authors: Mahircan Yagan, Sadia Najam, Ruiying Hu, Yu Wang, Mathew T Dickerson, Prasanna K...
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Jul 292 min read
COCA: a randomized Bayesian design integrating dose optimization and component contribution assessment for combination therapies
Date: April 2, 2025 PMID: 40552493 Category: N/A Authors: Xiaohan Chi, Ruitao Lin, Ying Yuan Abstract: In cancer treatment, the...
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Jul 292 min read
Immune surveillance of senescence: potential application to age-related diseases
Date: March 2025 PMID: https://doi.org/10.1016/j.tcb.2024.06.007 Category: N/A Authors: Teh-Wei Wang, Makoto Nakanishi Abstract: ...
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Jul 291 min read
Multidimensional analyses identify genes of high priority for pancreatic cancer research
Date: January 7, 2025 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC11949049/ Category: N/A Authors: Zeribe C Nwosu, Heather M Giza,...
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Jul 292 min read
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