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Integrated Metabolomics and Spatial Transcriptomics of Cystic Pancreatic Cancer Precursors Reveals Dysregulated Polyamine Metabolism as a Biomarker of Progression
Date: June 13, 2025 PMID: 40184234 Category: N/A Authors: Ricardo A León-Letelier, Yihui Chen, Rongzhang Dou, Ehsan Irajizad, Michele T...
bgtaylor1
Jul 292 min read
PIVOT: an open-source tool for multi-omic spatial data registration
Date: June 8, 2025 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC12259011/ Category: N/A Authors: André Forjaz, Valentina Matos Romero,...
bgtaylor1
Jul 291 min read
Targeting PIKfyve-driven lipid metabolism in pancreatic cancer
Date: June 2025 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC12176661/ Category: N/A Authors: Caleb Cheng, Jing Hu, Rahul Mannan,...
bgtaylor1
Jul 292 min read
Temporally discordant chromatin accessibility and DNA demethylation define short- and long-term enhancer regulation during cell fate specification
Date: May 27, 2025 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC12153380/ Category: N/A Authors: Lindsey N Guerin, Timothy J Scott,...
bgtaylor1
Jul 292 min read
Matrix Stiffness and Biochemistry Govern Colorectal Cancer Cell Growth and Signaling in User-Programmable Synthetic Hydrogels
Date: May 12, 2025 PMID: 40304602 Category: N/A Authors: Irina Kopyeva, Ross C Bretherton, Jessica L Ayers, Ming Yu, William M Grady,...
bgtaylor1
Jul 292 min read
Dipeptidase-1-knockout mice develop invasive tumors with features of microsatellite-unstable colorectal cancer
Date: April 3, 2025 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC12128987/ Category: N/A Authors: Sarah E Glass, Matthew E Bechard,...
bgtaylor1
Jul 292 min read
COMIC: A Bayesian Dose Optimization Design for Drug Combination in Multiple Indications With Application to CAR-T Therapies
Date: May 2025 PMID: 40386962 Category: N/A Authors: Kai Chen, Kentaro Takeda, Ying Yuan Abstract: Project Optimus, initiated by the...
bgtaylor1
Jul 292 min read
Multiomic spatial atlas shows deleted in malignant brain tumors 1 (DMBT1) glycoprotein is lost in colonic dysplasia
Date: May 2025 PMID: PMC11985286 Category: N/A Authors: Emily H Green, Subhag R Kotrannavar, Megan E Rutherford, Hannah M Lunnemann,...
bgtaylor1
Jul 292 min read
Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms Reveals Divergent Indolent and Malignant States
Date: May 1, 2025 PMID: 39969959 Category: N/A Authors: Matthew K Iyer, Ashley A Fletcher, Jude Ogechukwu Okoye, Chanjuan Shi, Fengming...
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Jul 292 min read
Atf4 Protects Islet β-Cell Identity and Function Under Acute Glucose-Induced Stress but Promotes β-Cell Failure in the Presence of Free Fatty Acid
Date: May 1, 2025 PMID: 39899446 Category: N/A Authors: Mahircan Yagan, Sadia Najam, Ruiying Hu, Yu Wang, Mathew T Dickerson, Prasanna K...
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Jul 292 min read
COCA: a randomized Bayesian design integrating dose optimization and component contribution assessment for combination therapies
Date: April 2, 2025 PMID: 40552493 Category: N/A Authors: Xiaohan Chi, Ruitao Lin, Ying Yuan Abstract: In cancer treatment, the...
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Jul 292 min read
Immune surveillance of senescence: potential application to age-related diseases
Date: March 2025 PMID: https://doi.org/10.1016/j.tcb.2024.06.007 Category: N/A Authors: Teh-Wei Wang, Makoto Nakanishi Abstract: ...
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Jul 291 min read
Multidimensional analyses identify genes of high priority for pancreatic cancer research
Date: January 7, 2025 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC11949049/ Category: N/A Authors: Zeribe C Nwosu, Heather M Giza,...
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Jul 292 min read
3D genomic mapping reveals multifocality of human pancreatic precancers
Date: May 2024 PMID: 38693266 Category: N/A Authors: Alicia M Braxton, Ashley L Kiemen, Mia P Grahn, André Forjaz, Jeeun Parksong, Jaanvi...
bgtaylor1
Nov 22, 20242 min read
VICTOR: Validation and inspection of cell type annotation through optimal regression
Date: 2 September 2024 PMID: PMC11408377 Category: N/A Authors: Chia-Jung Chang, Chih-Yuan Hsu, Qi Liu, Yu Shyr Abstract: ...
bgtaylor1
Nov 22, 20241 min read
3D histology reveals that immune response to pancreatic precancers is heterogeneous and depends on global pancreas structure
Date: 6 August 2024 PMID: PMC11326156 Category: N/A Authors: Ashley L Kiemen, Cristina Almagro-Pérez, Valentina Matos, Andre Forjaz,...
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Nov 22, 20242 min read
Chromogenic detection of telomere lengths in situ aids the identification of precancerous lesions in the prostate
Date: February 2024 PMID: PMC10843147 Category: N/A Authors: Onur Ertunc, Erica Smearman, Qizhi Zheng, Jessica L Hicks, Jacqueline A...
bgtaylor1
Nov 22, 20242 min read
Temporally discordant chromatin accessibility and DNA demethylation define short and long-term enhancer regulation during cell fate specification
Date: 27 August 24 PMID: PMC11383056 Category: N/A Authors: Lindsey N Guerin, Timothy J Scott, Jacqueline A Yap, Annelie Johansson, Fabio...
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Nov 22, 20242 min read
Phosphodiesterase-5 inhibition collaborates with vaccine-based immunotherapy to reprogram myeloid cells in pancreatic ductal adenocarcinoma
Date: 6 August 2024 PMID: PMC11457845 Category: N/A Authors: Nicole E Gross, Zhehao Zhang, Jacob T Mitchell, Soren Charmsaz, Alexei G...
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Nov 22, 20242 min read
PoweREST: Statistical Power Estimation for Spatial Transcriptomics Experiments to Detect Differentially Expressed Genes Between Two Conditions
Date: 1 September 2024 PMID: PMC11384012 Category: N/A Authors: Lan Shui, Anirban Maitra, Ying Yuan, Ken Lau, Harsimran Kaur, Liang Li,...
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Nov 22, 20242 min read
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