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COMIC: A Bayesian Dose Optimization Design for Drug Combination in Multiple Indications With Application to CAR-T Therapies
Date: May 2025 PMID: 40386962 Category: N/A Authors: Kai Chen, Kentaro Takeda, Ying Yuan Abstract: Project Optimus, initiated by the...
bgtaylor1
Jul 29, 20252 min read
Multiomic spatial atlas shows deleted in malignant brain tumors 1 (DMBT1) glycoprotein is lost in colonic dysplasia
Date: May 2025 PMID: PMC11985286 Category: N/A Authors: Emily H Green, Subhag R Kotrannavar, Megan E Rutherford, Hannah M Lunnemann,...
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Jul 29, 20252 min read
Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms Reveals Divergent Indolent and Malignant States
Date: May 1, 2025 PMID: 39969959 Category: N/A Authors: Matthew K Iyer, Ashley A Fletcher, Jude Ogechukwu Okoye, Chanjuan Shi, Fengming...
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Jul 29, 20252 min read
Atf4 Protects Islet β-Cell Identity and Function Under Acute Glucose-Induced Stress but Promotes β-Cell Failure in the Presence of Free Fatty Acid
Date: May 1, 2025 PMID: 39899446 Category: N/A Authors: Mahircan Yagan, Sadia Najam, Ruiying Hu, Yu Wang, Mathew T Dickerson, Prasanna K...
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Jul 29, 20252 min read
COCA: a randomized Bayesian design integrating dose optimization and component contribution assessment for combination therapies
Date: April 2, 2025 PMID: 40552493 Category: N/A Authors: Xiaohan Chi, Ruitao Lin, Ying Yuan Abstract: In cancer treatment, the...
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Jul 29, 20252 min read
Immune surveillance of senescence: potential application to age-related diseases
Date: March 2025 PMID: https://doi.org/10.1016/j.tcb.2024.06.007 Category: N/A Authors: Teh-Wei Wang, Makoto Nakanishi Abstract: ...
bgtaylor1
Jul 29, 20251 min read
Multidimensional analyses identify genes of high priority for pancreatic cancer research
Date: January 7, 2025 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC11949049/ Category: N/A Authors: Zeribe C Nwosu, Heather M Giza,...
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Jul 29, 20252 min read
3D genomic mapping reveals multifocality of human pancreatic precancers
Date: May 2024 PMID: 38693266 Category: N/A Authors: Alicia M Braxton, Ashley L Kiemen, Mia P Grahn, André Forjaz, Jeeun Parksong, Jaanvi...
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Nov 22, 20242 min read
VICTOR: Validation and inspection of cell type annotation through optimal regression
Date: 2 September 2024 PMID: PMC11408377 Category: N/A Authors: Chia-Jung Chang, Chih-Yuan Hsu, Qi Liu, Yu Shyr Abstract: ...
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Nov 22, 20241 min read
3D histology reveals that immune response to pancreatic precancers is heterogeneous and depends on global pancreas structure
Date: 6 August 2024 PMID: PMC11326156 Category: N/A Authors: Ashley L Kiemen, Cristina Almagro-Pérez, Valentina Matos, Andre Forjaz,...
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Nov 22, 20242 min read
Chromogenic detection of telomere lengths in situ aids the identification of precancerous lesions in the prostate
Date: February 2024 PMID: PMC10843147 Category: N/A Authors: Onur Ertunc, Erica Smearman, Qizhi Zheng, Jessica L Hicks, Jacqueline A...
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Nov 22, 20242 min read
Temporally discordant chromatin accessibility and DNA demethylation define short and long-term enhancer regulation during cell fate specification
Date: 27 August 24 PMID: PMC11383056 Category: N/A Authors: Lindsey N Guerin, Timothy J Scott, Jacqueline A Yap, Annelie Johansson, Fabio...
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Nov 22, 20242 min read
Phosphodiesterase-5 inhibition collaborates with vaccine-based immunotherapy to reprogram myeloid cells in pancreatic ductal adenocarcinoma
Date: 6 August 2024 PMID: PMC11457845 Category: N/A Authors: Nicole E Gross, Zhehao Zhang, Jacob T Mitchell, Soren Charmsaz, Alexei G...
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Nov 22, 20242 min read
PoweREST: Statistical Power Estimation for Spatial Transcriptomics Experiments to Detect Differentially Expressed Genes Between Two Conditions
Date: 1 September 2024 PMID: PMC11384012 Category: N/A Authors: Lan Shui, Anirban Maitra, Ying Yuan, Ken Lau, Harsimran Kaur, Liang Li,...
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Nov 22, 20242 min read
Consensus tissue domain detection in spatial omics data using multiplex image labeling with regional morphology (MILWRM)
Date: 30 October 2024 PMID: PMC11525554 Category: N/A Authors: Harsimran Kaur, Cody N Heiser, Eliot T McKinley, Lissa Ventura-Antunes,...
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Nov 22, 20242 min read
Accurate identification of locally aneuploid cells by incorporating cytogenetic information in single cell data analysis
Date: 15 October 2024 PMID: N/A Category: N/A Authors: Ziyi Li, Ruoxing Li, Irene Ganan-Gomez, Hussein A. Abbas, Guillermo Garcia-Manero...
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Nov 22, 20242 min read
EVPsort: An Atlas of Small ncRNA Profiling and Sorting in Extracellular Vesicles and Particles
Date: 1 September 2024 PMID: PMC11574917 Category: N/A Authors: Hua-Chang Chen, Jing Wang, Robert J Coffey, James G Patton, Alissa M...
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Nov 22, 20241 min read
Progressive Spreading of DNA Methylation in the GSTP1 Promoter CpG Island across Transitions from Precursors to Invasive Prostate Cancer
Date: 1 August 2023 PMID: PMC10529302 Category: N/A Authors: Harshath Gupta, Hitoshi Inoue, Yasutomo Nakai, Masashi Nakayama, Tracy...
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Nov 22, 20242 min read
A distribution-free and analytic method for power and sample size calculation in single-cell differential expression
Date: 4 September 2024 PMID: N/A Category: N/A Authors: Chih-Yuan Hsu, Qi Liu, Yu Shyr Abstract: Motivation Differential expression...
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Nov 22, 20242 min read
FindAdapt: A python package for fast and accurate adapter detection in small RNA sequencing
Date: 22 January 2024 PMID: PMC10833567 Category: N/A Authors: Hua-Chang Chen, Jing Wang, Yu Shyr, Qi Liu Abstract: Adapter trimming...
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Nov 22, 20241 min read
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