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Performance of the Oncuria-Detect bladder cancer test for evaluating patients presenting with haematuria: results from a real-world clinical setting
Date: June 18, 2025 PMID: PMC12178018 Category: N/A Authors: Ian Pagano, Zhen Zhang, Michael Luu, Sergei Tikhonenkov, Florence Le Calvez-Kelm, Steve Goodison, Toru Sakatani, Kaoru Murakami, Takashi Kobayashi, Patrice Avogbe, Howard Kim, Riko Lee, Arnaud Manel, Emmanuel Vian, Charles J Rosser, Hideki Furuya Abstract: 40533776 Background: Bladder cancer is the 9th most diagnosed cancer worldwide with high incidences reported in Europe and the United States. Here, we evaluated t
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Nov 11, 20252 min read
Practical Considerations for Using the TITE-BOIN Design to Handle Late-Onset Toxicity or Fast Accrual in Phase I Trials
Date: July 1, 2025 PMID: PMC12213182 Category: N/A Authors: Paste in the author's names... Abstract: 40327336 Conducting phase I trials is particularly challenging when dealing with late-onset dose-limiting toxicity (DLT) or when patient accrual is rapid relative to the DLT assessment window. In such cases, a new cohort may be ready for enrollment before the DLT assessments are complete for the current cohort, complicating dose assignment decisions. The time-to-event Bayesian
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Nov 11, 20252 min read
PS-SAM: propensity-score-integrated self-adapting mixture prior to dynamically and efficiently borrow information from historical data
Date: October 2025 PMID: PMC12353383 Category: N/A Authors: Yuansong Zhao, Peng Yang, Glen Laird, Josh Chen, Ying Yuan Abstract: 40243184 There has been growing interest in incorporating historical data to improve the efficiency of randomized controlled trials (RCTs) or reduce their required sample size. A key challenge is that the patient characteristics of the historical data may differ from those of the current RCT. To address this issue, a well-known approach is to e
bgtaylor1
Nov 11, 20252 min read
Overexpression of fibroblast activation protein (FAP) in the stroma of proliferative inflammatory atrophy (PIA) and primary adenocarcinoma of the prostate
Date: August 5, 2025 PMID: PMC12534906 Category: N/A Authors: Fernanda Caramella-Pereira, Qizhi Zheng, Jessica L Hicks, Sujayita Roy, Tracy Jones, Martin Pomper, Lizamma Antony, Alan K Meeker, Srinivasan Yegnasubramanian, Angelo M De Marzo, W Nathaniel Brennen Abstract: 40187966 Fibroblast activation protein (FAP) is a serine protease upregulated at sites of tissue remodelling and cancer that represents a promising therapeutic and molecular imaging target. In prostate cancer,
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Nov 11, 20252 min read
Targeting PIKfyve-driven lipid metabolism in pancreatic cancer
Date: June 2025 PMID: PMC12176661 Category: N/A Authors: Caleb Cheng, Jing Hu, Rahul Mannan, Tongchen He, Rupam Bhattacharyya, Brian Magnuson, Jasmine P Wisniewski, Sydney Peters, Saadia A Karim, David J MacLean, Hüseyin Karabürk, Li Zhang, Nicholas J Rossiter, Yang Zheng, Lanbo Xiao, Chungen Li, Dominik Awad, Somnath Mahapatra, Yi Bao, Yuping Zhang, Xuhong Cao, Zhen Wang, Rohit Mehra, Pietro Morlacchi, Vaibhav Sahai, Marina Pasca di Magliano, Yatrik M Shah, Lois S Weisman, J
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Nov 4, 20252 min read
A MULTIPLEX DIAGNOSTIC GENE EXPRESSION SIGNATURE STRATIFIES MUSCLE INVASIVE BLADDER CANCER INTO RESPONDERS VS. NON-RESPONDERS TO NEOADJUVANT CHEMOTHERAPY
Date: April 23, 2025 DOI: 10.1097/01.JU.0001109980.27536.57.34 Category: N/A Authors: Dai, YF (Dai, Yunfeng) ; Sakatani, T (Sakatani, Toru) ; Tanaka, S (Tanaka, Sunao) ; Black, P (Black, Peter) ; Rosser, CJ (Rosser, Charles J.) ; Furuya, H (Furuya, Hideki) Abstract: IP14-34 INTRODUCTION AND OBJECTIVE: Bladder cancer is a biologically heterogeneous disease with variable clinical presentation, outcome and response to therapy. Thus, the clinical utility of a single biomarker for
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Nov 4, 20252 min read
Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer
Date: June 2025 PMID: 40269162 Category: N/A Authors: Guangsheng Pei, Jimin Min, Kimal I Rajapakshe, Vittorio Branchi, Yunhe Liu, Benson Chellakkan Selvanesan, Fredrik Thege, Dorsay Sadeghian, Daiwei Zhang, Kyung Serk Cho, Yanshuo Chu, Enyu Dai, Guangchun Han, Mingyao Li, Cassian Yee, Kazuki Takahashi, Bharti Garg, Herve Tiriac, Vincent Bernard, Alexander Semaan, Jean L Grem, Thomas C Caffrey, Jared K Burks, Andrew M Lowy, Andrew J Aguirre, Paul M Grandgenett, Michael A Holli
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Nov 4, 20252 min read
Blebbisomes are large, organelle-rich extracellular vesicles with cell-like properties
Date: March 2025 PMID: PMC11906356 Category: N/A Authors: Dennis K Jeppesen, Zachary C Sanchez, Noah M Kelley, James B Hayes, Jessica Ambroise, Emma N Koory, Evan Krystofiak, Nilay Taneja, Qin Zhang, Matthew M Dungan, Olivia L Perkins, Matthew J Tyska, Ela W Knapik, Kevin M Dean, Amanda C Doran, Robert J Coffey, Dylan T Burnette Abstract: 39984653 Cells secrete a large variety of extracellular vesicles (EVs) to engage in cell-to-cell and cell-to-environment intercellular comm
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Nov 4, 20252 min read
Targeting PIKfyve-driven lipid metabolism in pancreatic cancer
Date: June 2025 PMID: PMC12176661 Category: N/A Authors: Caleb Cheng, Jing Hu, Rahul Mannan, Tongchen He, Rupam Bhattacharyya, Brian Magnuson, Jasmine P Wisniewski, Sydney Peters, Saadia A Karim, David J MacLean, Hüseyin Karabürk, Li Zhang, Nicholas J Rossiter, Yang Zheng, Lanbo Xiao, Chungen Li, Dominik Awad, Somnath Mahapatra, Yi Bao, Yuping Zhang, Xuhong Cao, Zhen Wang, Rohit Mehra, Pietro Morlacchi, Vaibhav Sahai, Marina Pasca di Magliano, Yatrik M Shah, Lois S Weisman, J
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Nov 4, 20252 min read
Integration of lipidomics with targeted, single cell, and spatial transcriptomics defines an unresolved pro-inflammatory state in colon cancer
Date: March 6, 2025 PMID: PMC11885055 Category: N/A Authors: Ramani Soundararajan, Michelle M Maurin, Jetsen Rodriguez-Silva, Gunjan Upadhyay, Ashley J Alden, Siddabasave Gowda B Gowda, Michael J Schell, Mingli Yang, Noah Jhad Levine, Divyavani Gowda, Punith M Sundaraswamy, Shu-Ping Hui, Lance Pflieger, Heiman Wang, Jorge Marcet, Carolina Martinez, Robert David Bennett, Allen Chudzinski, Andreas Karachristos, Timothy M Nywening, Paul M Cavallaro, Matthew Linley Anderson, Robe
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Nov 4, 20252 min read
Caspase-1-dependent pyroptosis converts αSMA+ CAFs into collagen-IIIhigh iCAFs to fuel chemoresistant cancer stem cells
Date: June 13, 2025 PMID: PMC12154229 Category: N/A Authors: Hongbo Gao, Stephen Q R Wong, Ethan Subel, Yung Hsing Huang, Yu-Cheng Lee, Kazukuni Hayashi, Mark Ellie Alonzo, Mustafa Karabicici, Xen Ping Hoi, Armine Kasabyan 1, Qianxing Mo, Zachary Melchiode, Ziad El-Zaatari, Steven Shen, Raj Satkunasivam, Fotis Nikolos, Keith Syson Chan Abstract: 40498841 The impact of chemotherapy-induced tumor cell pyroptosis on fibroblasts, a key stromal cell type within the tumor microenvi
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Nov 4, 20252 min read
Oncogenic and tumor-suppressive forces converge on a progenitor-orchestrated niche to shape early tumorigenesis
Date: June 12, 2025 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC12259082/ Category: N/A Authors: José Reyes, Isabella Del Priore, Andrea C Chaikovsky, Nikhita Pasnuri, Ahmed M Elhossiny, Tobias Krause, Andrew Moorman, Catherine Snopkowski, Meril Takizawa, Cassandra Burdziak, Nalin Ratnayeke, Ignas Masillioni, Yu-Jui Ho, Ronan Chaligné, Paul B Romesser, Aveline Filliol, Tal Nawy, John P Morris, Zhen Zhao, Marina Pasca Di Magliano, Direna Alonso-Curbelo, Dana Pe'er, Scott W
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Nov 4, 20252 min read
Thor: a platform for cell-level investigation of spatial transcriptomics and histology
Date: August 5, 2025 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC12325965/ Category: N/A Authors: Pengzhi Zhang, Weiqing Chen, Tu N Tran, Minghao Zhou, Kaylee N Carter, Ibrahem Kandel, Shengyu Li, Xen Ping Hoi, Yuxing Sun, Li Lai, Keith Youker, Qianqian Song, Yu Yang, Fotis Nikolos, Zejuan Li, Keith Syson Chan, John P Cooke, Guangyu Wang Abstract: 40764306 Spatial transcriptomics links gene expression with tissue morphology, however, current tools often prioritize genomic
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Nov 4, 20252 min read
Dipeptidase-1-knockout mice develop invasive tumors with features of microsatellite-unstable colorectal cancer
Date: April 3, 2025 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC12128987/ Category: N/A Authors: Sarah E Glass, Matthew E Bechard, Zheng Cao, Radhika Aramandla, Ping Zhao, Samuel T Ellis, Emily H Green, Elizabeth G Fisher, Ryan T Smith, Chelsie K Sievers, Maria Johnson Irudayam, Frank Revetta, M Kay Washington, Gregory D Ayers, Cody N Heiser, Alan J Simmons, Yanwen Xu, Yu Wang, Annika Windon, Martha J Shrubsole, Nicholas O Markham, Qi Liu, Ken S Lau, Robert J Coffey Abstra
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Nov 4, 20252 min read
Integrated Metabolomics and Spatial Transcriptomics of Cystic Pancreatic Cancer Precursors Reveals Dysregulated Polyamine Metabolism as a Biomarker of Progression
Date: June 13, 2025 PMID: 40184234 Category: N/A Authors: Ricardo A León-Letelier, Yihui Chen, Rongzhang Dou, Ehsan Irajizad, Michele T Yip-Schneider, Ranran Wu, Rahmah Ejaz, Hamid K Rudsari, Yaxi Li, Rachelle Spencer, Riccardo Ballarò, Jody Vykoukal, Mark Hurd, Jennifer B Dennison, Kim-Anh Do, Anirban Maitra, Jianjun Zhang, Samir Hanash, C Max Schmidt, Johannes F Fahrmann Abstract: Purpose: We conducted metabolomics and spatial cell transcriptomics of intraductal papill
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Jul 29, 20252 min read
PIVOT: an open-source tool for multi-omic spatial data registration
Date: June 8, 2025 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC12259011/ Category: N/A Authors: André Forjaz, Valentina Matos Romero,...
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Jul 29, 20251 min read
Targeting PIKfyve-driven lipid metabolism in pancreatic cancer
Date: June 2025 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC12176661/ Category: N/A Authors: Caleb Cheng, Jing Hu, Rahul Mannan,...
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Jul 29, 20252 min read
Temporally discordant chromatin accessibility and DNA demethylation define short- and long-term enhancer regulation during cell fate specification
Date: May 27, 2025 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC12153380/ Category: N/A Authors: Lindsey N Guerin, Timothy J Scott,...
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Jul 29, 20252 min read
Matrix Stiffness and Biochemistry Govern Colorectal Cancer Cell Growth and Signaling in User-Programmable Synthetic Hydrogels
Date: May 12, 2025 PMID: 40304602 Category: N/A Authors: Irina Kopyeva, Ross C Bretherton, Jessica L Ayers, Ming Yu, William M Grady,...
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Jul 29, 20252 min read
Dipeptidase-1-knockout mice develop invasive tumors with features of microsatellite-unstable colorectal cancer
Date: April 3, 2025 PMID: https://pmc.ncbi.nlm.nih.gov/articles/PMC12128987/ Category: N/A Authors: Sarah E Glass, Matthew E Bechard,...
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Jul 29, 20252 min read
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