Date: January 16, 2026 PMID: PMC12821410 Category: N/A Authors: Nisha Ganesh, William M Grady, Andrew M Kaz Abstract: Colitis-associated colorectal cancer (CAC) represents a distinct subtype of colorectal malignancy that arises in the setting of chronic inflammatory bowel disease (IBD). Unlike sporadic colorectal cancer, CAC develops through inflammation-driven molecular pathways, in which epigenetic alterations play a pivotal role in tumor initiation and progression. Th