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Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia
Date: December 23, 2025 PMID: PMC12860476 Category: N/A Authors: Vincent Quoc-Huy Trinh, Katherine E Ankenbauer, Sabrina M Torbit, Christopher P Taranto, Jiayue Liu, Maelle Batardiere, Bhoj Kumar, H Carlo Maurer, Frank Revetta, Zhengyi Chen, Angela R S Kruse, Audra M Judd, Celina Copeland, Jahg Wong, Olivia Ben-Levy, Brenda Jarvis, Monica Brown, Jeffrey W Brown, Koushik Das, Yuki Makino, Jeffrey M Spraggins, Ken S Lau, Parastoo Azadi, Anirban Maitra, Marcus C B Tan, Kathleen
bgtaylor1
Feb 242 min read
Accurate imputation of pathway-specific gene expression in spatial transcriptomics with PASTA
Date: December 16, 2025 PMID: PMC12820036 Category: N/A Authors: Ruoxing Li, Peng Yang, Mauro Di Pilato, Jianjun Zhang, Christopher R Flowers, Lulu Shang 7, Ziyi Li Abstract: Mapping the entire transcriptome at single-cell resolution under its natural spatial context is essential for investigating the oncogenesis and progression of diseases. The recently emerged targeted in-situ technologies retain the spatial organization of cells at high resolution, although they remai
bgtaylor1
Feb 242 min read
Developing a prediction model in a large case-control study for the early detection of bladder cancer
Date: December 5, 2025 PMID: PMC12797399 Category: N/A Authors: Sunao Tanaka, Lynne R Wilkens, Loïc Le Marchand, Gong Yang, Jian-Min Yuan, Woon-Puay Koh, Martha J Shrubsole, Michael Luu, Ian Pagano, Jane C Figueiredo, Hideki Furuya, Charles J Rosser Abstract: Background: Bladder cancer (BCa) is a lethal cancer, but early-detection offers an opportunity to improve prognosis. Our objective was to develop a urine-based multi-marker panel for BCa detection across multiple lo
bgtaylor1
Feb 242 min read
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