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Microenvironment-aware spatial modeling for accurate inference of cell identity
Date: January 5, 2026 PMID: PMC12774649 Category: N/A Authors: Qi Liu, Yu Wang, Chih-Yuan Hsu, Celestine N Wanjalla, Ken S Lau, Yu Shyr DOI: 10.1093/nar/gkaf1477 Spatial omics technologies enable the simultaneous measurement of molecular features within their spatial context, providing unprecedented insights into cellular organization and tissue architecture. The advent of single-cell resolution platforms has further enhanced our ability to uncover microenvironment-depend
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Feb 242 min read
Fibroblast STAT3 Activation Drives Organ-Specific Premetastatic Niche Formation
Date: January 2 2026 PMID: PMC12757723 Category: N/A Authors: Emily L Lasse Opsahl, Carlos E Espinoza, Alberto C Olivei, Jude Ogechukwu Okoye, Hannah Watkoske, Megan T Hoffman, Faith R Avritt, Ahmed M Elhossiny, Allison C Bischoff, Katelyn L Donahue, Mary Poggi, Padma Kadiyala, Nandini Arya, Jiaqi Shi, Kyoung Eun Lee, Yaqing Zhang, Eileen S Carpenter, Julianne M Szczepanski, Timothy L Frankel, Marina Pasca di Magliano Abstract: Pancreatic cancer is associated with a high
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Feb 242 min read
Combined MYC Activation and PTEN Loss Drives Molecular Features of Aggressive Preinvasive Lesions in Mouse Prostate
Date: January 2 2026 PMID: 41081599 Category: N/A Authors: Michael Rubenstein, Apurv Rege, Gretchen Hubbard, Danielle Cannady, Shreya Agarwal, Kevin Chen, Alex Estrada, Carolina Gomes-Alexandre, Jessica Hicks, Tracy Jones, Qizhi Zheng, Srinivasan Yegnasubramanian, Charles J Bieberich, Angelo M De Marzo DOI: 10.1158/1541-7786.MCR-24-1206 Prostate cancer ranges from indolent to rapidly progressive. An elevated cell proliferation index portends poor outcomes, yet the molecul
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Feb 242 min read
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